Lumbar Vein Embolization for Chronic Headaches With Nutcracker Physiology

This study is testing whether blocking certain veins in the lower back (lumbar vein embolization) can relieve chronic daily headaches linked to a condition called nutcracker physiology — a compression of a major abdominal vein that may affect fluid pressure around the brain. **You may be eligible if...** - You have had daily headaches lasting more than 3 months - Your headaches feel like pressure - Your headaches get worse when you tilt your head down (Trendelenburg position) - You have tried medications that lower cerebrospinal fluid (CSF) pressure or volume - You have tried at least 2 of these medications (unless contraindicated): acetazolamide, methazolamide, indomethacin, or topiramate **You may NOT be eligible if...** - Your headaches are not pressure-type or positional - You have not tried the appropriate medications - You do not have evidence of nutcracker physiology on imaging Talk to your doctor to see if this trial is right for you.