RecruitingNCT06182215
PostoperAtive Neurocognitive Dysfunction After Major AbdomiNal Surgery (PANDAMAN)
Postoperative Neurocognitive Dysfunction After Major Abdominal Surgery: A Prospective Observational Cohort Study
Sponsor
Sixth Affiliated Hospital, Sun Yat-sen University
Enrollment
500 participants
Start Date
Dec 11, 2023
Study Type
OBSERVATIONAL
Conditions
Summary
Predisposing and precipitating factors for perioperative delirium for the elderly remain elusive. This research will be conducted to determine risk factors of postoperative delirium.
Eligibility
Min Age: 65 YearsMax Age: 90 Years
Inclusion Criteria2
- to 90 years old to receive elective major abdominal surgery (expected operation time over 2 hours); ,
- American society of Aneshesiologists（ASA）physical status I-III;
Exclusion Criteria7
- Mini-Mental State Examination (MMES) score \< 15;
- Renal failure (requiring dialysis) or liver failure (Child-Pugh score \> 5);
- Severe impairment due to structural or hypoxic brain injury, more than 2 days in ICU one month before surgery;
- Underwent major heart, lung or abdominal surgery within 1 year;
- Positive for Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or symptomatic (e.g. fever, cough, loss of taste/smell);
- The cognitive assessment cannot be completed because the subject is blind, deaf, or unable to communicate in the local language;
- Long-term follow-up unavailable (homelessness, active psychosis or substance abuse).
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Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06182215