Hitting the Mark: Introducing State-of-the-art MRI for Precision Radiotherapy of Glioblastoma
Erasmus Medical Center
53 participants
Jan 3, 2024
INTERVENTIONAL
Conditions
Summary
The goal of this prospective cohort study is to assess the potential of advanced MRI for improved radiotherapy target delineation in patients diagnosed with glioblastoma. The main questions it aims to answer are: * How does the coverage of the recurrence volume by a radiotherapy plan based on advanced MRI compare to the coverage by the clinical radiotherapy plan? * How does the distribution of the dose to organs at risk by a radiotherapy plan based on advanced MRI compare to the distribution by the clinical radiotherapy plan? Participants will undergo an extended MRI-protocol prior to radiotherapy. This extended MRI-protocol includes the clinical brain tumor imaging protocol plus additional advanced MRI-sequences. Radiation treatment and patient follow-up will occur according to the clinical standard.
Eligibility
Inclusion Criteria4
- Written informed consent;
- Adult (18 years or older);
- Diagnosed with IDH-wildtype glioblastoma, as confirmed by pathology including molecular analysis post resection/biopsy;
- Referred to the outpatient clinic of the Dept. of Radiotherapy to undergo standard treatment with radiotherapy (30x2 Gy or 15x2.67Gy or 10x3.4Gy).
Exclusion Criteria5
- Contraindication for (3 Tesla) MRI;
- Contraindication for use of gadolinium-based contrast agent (e.g. subject having renal deficiency or known allergy);
- Referred for treatment of recurrent glioblastoma;
- Previous radiotherapy to the brain;
- Unable to give informed consent
Interventions
The MRI-protocol before radiotherapy is extended with 20 minutes. Patients who would not have received an MRI-scan prior to radiotherapy, will get an extra MRI-scan when participating.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06183983