ITGA6 Targeting NIR-II Fluorescence Image Guided Surgery
ITGA6 Targeting NIR-II Fluorescence Image Guided Surgery of HCC Patients
Institute of Automation, Chinese Academy of Sciences
90 participants
Jan 7, 2024
INTERVENTIONAL
Conditions
Summary
In this study, the investigators will detect hepatocellular carcinoma lesions using fluoescence imaging with ITGA6 targeting probes during tumor resection surgery. The aim is to evaluate wether intraoperative fluorescence imaging targeting ITGA6 can help to improve the detction effect of hepatocellular carcinoma, and finally help the accurate surgical resection. The main purposes of this study include: 1. To raise the detection rate of hepatocellular carcinoma intraoperatively using the novel NIR-II fluorescence molecular imaging and the ITGA6 targeting probe. 2. To validate the safety and effectiveness of the proposed ITGA6 targeting probes for clinical application.
Eligibility
Inclusion Criteria6
- Patients who have been diagnosed with hepatocellular carcinoma.
- Planned to receive hepatectomy.
- Liver function Child-Pugh A.
- ITGA6 was validated highly expressed preoperatively.
- Aged 18 to 80, and the expected lifetime is longer than 6 months.
- Approved to sign the informed consent.
Exclusion Criteria6
- Allergic to Cy7.
- Enrolled in other trials in the past 3 months.
- Another malignant tumor was found.
- Undesirable function of heart, lung, kidney, or any other organs.
- Unable to tolerate a hepatectomy.
- The researchers considered inappropriate to be included.
Interventions
Fluorophore targeting ITGA6 that is overexpressed in HCC cells
Locations(2)
View Full Details on ClinicalTrials.gov
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NCT06204835