RecruitingNot ApplicableNCT06220721

Reducing the Risk of Chronic Hypertension and Improving Vascular Function Following Preeclampsia


Sponsor

Medical College of Wisconsin

Enrollment

618 participants

Start Date

Oct 23, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The long-term goal of our work is to evaluate the effect of intensive postpartum blood pressure control on maternal cardiovascular health, risk of chronic hypertension, and reversal of vascular dysfunction generated by hypertensive disorders of pregnancy, thus attenuating the lifelong trajectory of cardiovascular disease risk.


Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial is testing whether a structured postpartum care program — including a blood pressure medication called nifedipine ER — can reduce the risk of developing chronic high blood pressure and improve blood vessel health in women who experienced a high blood pressure complication during pregnancy (such as preeclampsia or gestational hypertension). **You may be eligible if...** - You were diagnosed with a pregnancy-related high blood pressure disorder (preeclampsia, gestational hypertension, eclampsia, or HELLP syndrome) - You are within 0–4 days postpartum (just after delivery) - You are 18 or older and speak English or Spanish - You have an established OB/GYN provider in the study health system **You may NOT be eligible if...** - You had high blood pressure before your pregnancy - You have type 1 or type 2 diabetes - You are in the intensive care unit at the time of screening - You have a known allergy to nifedipine ER or a contraindication to it - You are already on long-acting blood pressure medication for standard care - You have sickle cell disease or lupus Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGNifedipine ER

Initiation of nifedipine ER postpartum at randomly assigned threshold during the first 6 weeks postpartum.


Locations(2)

Northwestern University

Chicago, Illinois, United States

Medical College of Wisconsin

Milwaukee, Wisconsin, United States

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NCT06220721


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