RecruitingNot ApplicableNCT06220721
Reducing the Risk of Chronic Hypertension and Improving Vascular Function Following Preeclampsia
Sponsor
Medical College of Wisconsin
Enrollment
618 participants
Start Date
Oct 23, 2024
Study Type
INTERVENTIONAL
Conditions
Summary
The long-term goal of our work is to evaluate the effect of intensive postpartum blood pressure control on maternal cardiovascular health, risk of chronic hypertension, and reversal of vascular dysfunction generated by hypertensive disorders of pregnancy, thus attenuating the lifelong trajectory of cardiovascular disease risk.
Eligibility
Sex: FEMALEMin Age: 18 Years
Inclusion Criteria5
- Hypertensive disorders of pregnancy (HDP) diagnosis, specifically gestational hypertension, preeclampsia, eclampsia, or HELLP syndrome, according to ACOG guidelines
- Postpartum day 0-4
- Age ≥ 18 years
- Able to communicate in English or in Spanish
- Has an established OBGYN at an MCW or NU health system practice that has access to Epic electronic medical records.
Exclusion Criteria9
- Pre-gestational hypertension
- Type 1 or type 2 diabetes mellitus
- Admitted to intensive care unit at the time of screening
- Diagnosed with HDP during postpartum readmission after discharge from delivery hospitalization
- Getting discharged on the day of screening
- Known allergy or contraindication to nifedipine ER
- Inability or unwillingness to provide informed consent
- Already taking long-acting antihypertensive medication for standard care
- Maternal conditions that impact study outcomes: sickle cell disease, systemic lupus erythematosus
Interventions
DRUGNifedipine ER
Initiation of nifedipine ER postpartum at randomly assigned threshold during the first 6 weeks postpartum.
Locations(2)
View Full Details on ClinicalTrials.gov
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NCT06220721
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