Microbiota in Gastric Cancer by Gastric Mucosal Brushing
Microbiota Diversity and Composition in Gastric Cancer by Gastric Mucosal Brushing: a Cross-sectional Case-control Study
King Chulalongkorn Memorial Hospital
40 participants
Feb 1, 2024
OBSERVATIONAL
Conditions
Summary
Many studies have shown a significant change of diversity and composition in gut microbiota across the gastric carcinogenesis process, particularly in patients with gastric cancer. However, there has been no analysis of gastric microbiota using the mucosal brushing technique, despite its favoring benefit in microbiota study. Therefore, this study aims to evaluate microbiota profile in patients with gastric cancer, compared to those without gastric cancer by using mucosal brush sampling. This will improve current knowledge of the potential role of the microbiome in patient gastric cancer as a future biomarker marker using brushing sampling.
Eligibility
Inclusion Criteria4
- Adult patients (≥18 years of age) and undergoing esophagogastroduodenoscopy (EGD)
- Gastric cancer group: patients with pathological diagnosis of high-grade dysplasia or gastric cancer
- Control group: patients with no or minimal upper GI symptoms and current EGD appear normal or minimal gastritis
- Informed consent obtained
Exclusion Criteria3
- Had a history of GI or hepatobiliary surgery
- Had a history of recent (within 4 weeks) antibiotic or probiotic use
- Had a history of PPI use within 2 weeks
Interventions
Gastric mucosal brushing will be performed at body of stomach in control group and non-tumorous area of body in gastric cancer group. If gastric body area could not feasible (eg. tumor involvement), then gastric antrum and more proximal part of body will be sampling.
Gastric mucosal biopsy will be performed at the area within 2 cm. from brushing site.
Locations(2)
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NCT06325891