RecruitingNCT06326879
A Comparative Study Between Early Onset Colorectal Cancer and Late Onset Colorectal Cancer Patients
Early-Onset Colorectal Cancer Versus Late-Onset Colorectal Cancer: a Prospective Observational Cohort Study to Explore the Clinical, Sociodemographic, Genetic, and Molecular Characteristics Associated With Adverse Oncological Outcomes (
Sponsor
Istituto Clinico Humanitas
Enrollment
340 participants
Start Date
Nov 30, 2023
Study Type
OBSERVATIONAL
Conditions
Summary
This study aims to investigate the clinical, socioeconomic, behavioral, genetic, and molecular factors characterizing Early Onset Colorectal Cancer (EOCRC) patients compared with Late Onset Colorectal Cancer (LOCRC) patients
Eligibility
Min Age: 18 Years
Inclusion Criteria6
- Patients aged more than 18 years old at the time of inclusion.
- Patients with a proven diagnosis of colorectal adenocarcinoma, as reported by the staging histological biopsies.
- Patients with a preoperative staging I-III.
- Patients scheduled for elective curative colorectal resection.
- Patients with rectal cancer who underwent neoadjuvant therapy can be included in the study.
- Patients able and willing to comply with the protocol requirements (samples' collection and questionnaires' compilation).
Exclusion Criteria8
- Patients with metastatic disease at diagnosis.
- Patients requiring an emergent procedure.
- Patients undergoing palliative surgery (for example, fecal diversion).
- Patients with a surgical indication for benign lesions (for example, adenoma or dysplasia).
- Patients with an intraoperative finding of a lesion other than adenocarcinoma will be withdrawn from the study.
- Patients with an intraoperative finding of distal metastasis or peritoneal carcinosis will be withdrawn from the study.
- Patients with a concomitant diagnosis of Inflammatory Bowel Disease.
- Patients with a known genetic syndrome (for example, Lynch syndrome or Familial Adenomatous Polyposis).
Interventions
OTHERNo intervention
Questionnaires compilation and sample collection
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06326879
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