RecruitingPhase 4NCT06332781
Intravesical Gentamicin to Prevent Recurrent UTI
Sponsor
Women and Infants Hospital of Rhode Island
Enrollment
30 participants
Start Date
Apr 28, 2025
Study Type
INTERVENTIONAL
Conditions
Summary
Feasibility assessment of intravesical gentamicin instillation (putting antibiotics directly into the bladder) versus the current standard of care of oral nitrofurantoin prophylaxis (taking a low dose of antibiotics by mouth every day) to prevent recurrent urinary tract infections (UTI)
Eligibility
Sex: FEMALEMin Age: 40 Years
Inclusion Criteria3
- Postmenopausal
- UTIs in 6 months
- desire to start antibiotic prophylaxis to prevent UTIs
Exclusion Criteria14
- Parkinsons disease
- myasthenia gravis
- renal failure
- liver failure
- bladder pain syndrome
- multiple negative urine cultures associated with UTI symptoms (>/= 3)
- bladder Botox treatments in the past
- treatment planned for UI and prolapse
- unevaluated microscopic hematuria
- history of kidney stones
- no antibiotics within 4 weeks
- most recent weight <40kg (88.18lbs)
- surgically altered urinary tract (urinary diversion, phalloplasty, etc)
- allergy or hypersensitivity to either of the study medications or medications in the same family including but not limited to: amikacin, kanamycin, neomycin, paromomycin, streptomycin, tobramycin.
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
DRUGGentamicin
administered via bladder
DRUGNitrofurantoin
administered PO
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06332781