NOvel Immunotherapy Strategies for Advanced Triple Negative Breast Cancer (TNBC) Patients: TONIC-3 Trial

This study tests new combinations of immunotherapy drugs for people with advanced triple-negative breast cancer (TNBC) — an aggressive form of breast cancer that doesn't respond to hormone therapies — who have already received prior treatments. **You may be eligible if...** - You are 18 or older with confirmed advanced or metastatic triple-negative breast cancer - You have received at least one prior treatment for advanced disease - Your general health is reasonably good and your organ function is within acceptable limits **You may NOT be eligible if...** - You have active autoimmune disease or are receiving immunosuppressive therapy - You have uncontrolled brain metastases - You have serious heart, lung, or liver disease - You are pregnant or breastfeeding - You have had a severe allergic reaction to any immunotherapy Talk to your doctor to see if this trial is right for you.