RecruitingPhase 2NCT06378346

GU-01: Glycyrrhizin in Prostate Cancer

GU-01: Glycyrrhizin in Prostate Cancer: A Window-of-Opportunity Trial

Sponsor

University of Illinois at Chicago

Enrollment

60 participants

Start Date

Jul 25, 2024

Study Type

INTERVENTIONAL

Conditions

Prostate Cancer

Summary

This is a pilot, randomized, window-of-opportunity treatment trial in which participants with previously untreated prostate cancer (PCa) who are candidates for surgery (radical prostatectomy)

Eligibility

Sex: MALEMin Age: 18 Years

Inclusion Criteria6

Age ≥ 18 years of age at time of consent
ECOG performance status of 0, 1, or 2
Histologic diagnosis of prostate cancer
Patient suitable for radical prostatectomy as determined by surgical team
Able to provide written informed consent and HIPAA authorization for release of personal health information, via an approved UIC Institutional Review Board (IRB) informed consent form and HIPAA authorization.
Willing to use barrier contraceptive method during study intervention

Exclusion Criteria4

Any prior or concurrent malignancy whose natural history or treatment has the potential to interfere with the safety or efficacy assessment of this investigational regimen, as determined by the treating urologic oncology team.
Previous chemotherapy, biological therapy, radiation therapy, androgens, thalidomide, immunotherapy, other anticancer agents and/or investigational agents within 30 days of starting study treatment.
Potent or moderate inhibitors and inducers of CYP3A4 if taken within a 1 week wash-out period
Concomitant medications known to prolong QT interval, or with factors that increase the risk of QTc prolongation, or History of Torsades de Pointes. This may include patients who have sub-optimally controlled hypertension, serum potassium levels \<4.0 mEq/L, serum magnesium ≤1.8 mg/dL, prolonged gastrointestinal transit time, or decreased 11-β-hydroxysteriod dehydrogenase-2 activity.