RecruitingNot ApplicableNCT06391970

Digital Cognition Study During Long-COVID

Exploring Long-COVID Impact on Cognition Through Digital Neuropsychological Assessment


Sponsor

Luxembourg Institute of Health

Enrollment

300 participants

Start Date

Apr 15, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

The persistence of the COVID-19 disease symptoms, such as extreme fatigue, shortness of breath, cardiovascular complications, depression and anxiety, pain, brain fog, loss of taste/smell, headaches as well as loss of memory has been evoked in many studies. This project aims at approaching the persistent symptomatology on cognition, more than 1 year after the infection. When we refer to cognition, we refer to everything associated with knowledge, that is, the accumulation of information we have acquired through learning or from our experience. We can define cognitive processes as the processes we use to incorporate new knowledge and make decisions based on it. Through these processes several cognitive functions intervene: perception, attention, memory, reasoning, language, learning, decision-making. All of these cognitive functions work together to integrate knowledge as a whole and create an interpretation of the world around us. Usually neuropsychological tests are used to evaluate cognitive problems, they consist in different exercises sometimes with words, figures to draw, images to remember, movement to repeat, numbers to link together etc. The DigiCog project here propose 1. to test and validate a very novel device, which uses the eyes movement during tasks to evaluate very quickly the cognitive functioning; 2. to study potential cognitive problems long-term after COVID-19; and 3. to explore how cognition could be preserved. Finally, this project will also help to bring the innovative device tested to the market, for accurately monitoring people with long COVID.


Eligibility

Min Age: 25 YearsMax Age: 65 Years

Inclusion Criteria3

  • Participants who have previously participated in the Predi-COVID study (Registration number NCT04380987), or who have experienced COVID-19 at least once before 2022.
  • Participants who have signed the informed consent form
  • Participants aged between 25 and 65 years old

Exclusion Criteria3

  • Psychological or neurological disorders history especially those detected before the COVID-19 disease (e.g. epilepsy, stroke, chronic fatigue) as well as treatment that could interfere with the assessment (e.g., antipsychotics, antidepressants, mood stabilizers, antiepileptics, benzodiazepines)
  • Poor eyesight, rendering the use of the digital device impossible
  • Inability to speak the proposed languages

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Interventions

DEVICECognitive screening

The cognitive abilities of participants will be assessed using two different interventions: the first utilizing the new digital device, and the second employing the gold standard method.


Locations(1)

Luxembourg Institute of Health, LCTR

Luxembourg, Luxembourg

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NCT06391970


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