RecruitingPhase 3NCT06393868

Reducing Gastrointestinal Bleeding With Proton Pump Inhibitor Therapy in Acute Venous Thromboembolism

Reducing Gastrointestinal Bleeding With Proton Pump Inhibitor Therapy in Acute Venous Thromboembolism: Pilot Randomized Study (RADIANT Study)

Sponsor

Ottawa Hospital Research Institute

Enrollment

360 participants

Start Date

Nov 6, 2024

Study Type

INTERVENTIONAL

Conditions

Venous Thromboembolism Gastro Intestinal Bleeding Blood Clot

Summary

The investigators are studying whether treatment with a proton pump inhibitor called omeprazole reduces gastrointestinal bleeding in older adults taking blood thinners for a blood clot (venous thromboembolism). The purpose of this study, a pilot study or a feasibility study, is to test the study plan and determine whether enough participants will join a larger study and accept the study procedures.

Eligibility

Min Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Omeprazole 20 mg Oral Tablet and Placebo for people with blood clot, gastro intestinal bleeding, and other related conditions. The study is currently recruiting participants at 7 locations. People eligible for this study include aged 65 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGOmeprazole 20 mg Oral Tablet

Omeprazole once daily for 90 days

OTHERPlacebo

Placebo once daily for 90 days

Locations(7)

The Ottawa Hospital

Ottawa, Ontario, Canada

Niagara Health System - St. Catharines Site

St. Catharines, Ontario, Canada

University Health Network - Toronto General

Toronto, Ontario, Canada

CIUSSS de l'Est-de- l'Île-de-Montréal

Montreal, Quebec, Canada

Centre hospitalier de l'Université de Montréal

Montreal, Quebec, Canada

CHU de Québec-Université Laval; Hôpital Saint-François d'Assise

Québec, Quebec, Canada

Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval

Québec, Quebec, Canada

View Full Details on ClinicalTrials.gov

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NCT06393868

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