Comparing Moderately Ultra Hypofractionated Radiation Treatments for Prostate Cancer

This trial compares two radiation therapy schedules for men who had their prostate removed and now need post-surgery radiation. One schedule delivers radiation every other day at a higher dose (ultrahypofractionated); the other delivers radiation daily at a moderate dose. Both aim to kill remaining cancer cells, but in fewer total visits. **You may be eligible if...** - You are over 18 years old with a biopsy-confirmed prostate cancer diagnosis - You had your prostate removed (radical prostatectomy) more than 6 months ago - You are in good health (ECOG 0–1) - You are scheduled to receive post-operative radiation therapy **You may NOT be eligible if...** - You have had prior pelvic radiation therapy - There is visible cancer remaining in the prostate bed or pelvic lymph nodes on imaging - Your cancer has spread to other parts of the body Talk to your doctor to see if this trial is right for you.