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RecruitingNot ApplicableNCT06426173

Effect of Resistance Training in Patients on the Waiting List for Heart Transplant

Effect of Resistance Training on Functional Capacity, Quality of Life and Cardiac Biomarkers in Patients on the Waiting List for Heart Transplant: a Randomized and Controlled Clinical Trial

Sponsor

University of Sao Paulo General Hospital

Enrollment

50 participants

Start Date

Jun 18, 2024

Study Type

INTERVENTIONAL

Conditions

Heart FailureHeart Transplant

Summary

The present longitudinal, randomized, and blinded clinical trial aims to: * Evaluate the effects of resistance training on the functional capacity, quality of life, and cardiac biomarkers of hospitalized patients with heart failure (HF) on the waiting list for heart transplantation (HTx). * Evaluate the associations between Fried's frailty classification and functional capacity responses to resistance training. The protocol will have a total duration of 12 weeks.

Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether resistance training (strength exercises) is safe and beneficial for patients who are on the heart transplant waiting list. It aims to see whether exercising in a supervised way helps maintain or improve muscle strength and function while waiting for a new heart. **You may be eligible if...** - You have been placed on the heart transplant waiting list within the past month - Your blood pressure and heart rate are stable (within defined safe ranges for at least 48 hours) - You are on a low or moderate dose of dobutamine (a heart support medication, ≤10 mcg/kg/min) **You may NOT be eligible if...** - Your heart failure is caused by abnormal heart rhythms (arrhythmogenic) or a stiffened heart (restrictive cardiomyopathy) - You have uncontrolled abnormal heart rhythms - You have a cognitive, orthopedic, or neuromuscular condition that prevents exercise testing Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERResistance Training Program

The resistance training program will be individualized and divided into four stages of increasing complexity. It will be conducted for approximately 40 minutes per day, three times a week, for 12 weeks, under supervision. Each patient will begin the program at the stage corresponding to their functional capacity. The resistance load will be set at 50% of the maximum resistance (1RM) obtained in the initial assessment. Throughout all stages of the exercise program, the target intensity will range from light (≤ 12) to moderate (≤ 15) on the Borg scale.

OTHERStandard Treatment Group

Patients will receive the standard treatment provided by the hospital inpatient unit, which includes guidance on reducing sedentary time, encouragement to walk, and performance of active and breathing exercises when necessary.

Locations(1)

Instituto do Coração - Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

São Paulo, São Paulo, Brazil

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NCT06426173

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