Effect of Resistance Training in Patients on the Waiting List for Heart Transplant
Effect of Resistance Training on Functional Capacity, Quality of Life and Cardiac Biomarkers in Patients on the Waiting List for Heart Transplant: a Randomized and Controlled Clinical Trial
University of Sao Paulo General Hospital
50 participants
Jun 18, 2024
INTERVENTIONAL
Conditions
Summary
The present longitudinal, randomized, and blinded clinical trial aims to: * Evaluate the effects of resistance training on the functional capacity, quality of life, and cardiac biomarkers of hospitalized patients with heart failure (HF) on the waiting list for heart transplantation (HTx). * Evaluate the associations between Fried's frailty classification and functional capacity responses to resistance training. The protocol will have a total duration of 12 weeks.
Eligibility
Inclusion Criteria3
- patients included in heart transplant list ≤1 month
- hemodynamically stable in the last 48 hours defined as mean arterial pressure (MAP) ≥ 60 mmHg and ≤ 120 mmHg and - Heart rate (HR) ≥ 60 bpm and ≤ 120 mmHg.
- dobutamine dose ≤ 10 mcg/kg/min
Exclusion Criteria3
- heart failure of arrhythmogenic and/or restrictive etiology
- presence of uncontrolled acute arrhythmias
- cognitive, orthopedic, or neuromotor changes that prevent functional tests from being carried out
Interventions
The resistance training program will be individualized and divided into four stages of increasing complexity. It will be conducted for approximately 40 minutes per day, three times a week, for 12 weeks, under supervision. Each patient will begin the program at the stage corresponding to their functional capacity. The resistance load will be set at 50% of the maximum resistance (1RM) obtained in the initial assessment. Throughout all stages of the exercise program, the target intensity will range from light (≤ 12) to moderate (≤ 15) on the Borg scale.
Patients will receive the standard treatment provided by the hospital inpatient unit, which includes guidance on reducing sedentary time, encouragement to walk, and performance of active and breathing exercises when necessary.
Locations(1)
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NCT06426173