3D Printed Custom Applicators for HDR BT (DISCO)

This study (called DISCO) is testing 3D-printed, custom-made applicators used to deliver internal radiation therapy (called high-dose rate brachytherapy) for women with gynecological cancers. The goal is to see if these personalized devices improve treatment precision. **You may be eligible if...** - You can give informed consent - You are scheduled to receive internal radiation therapy (intracavitary brachytherapy) - You have been diagnosed with primary endometrial cancer, primary vaginal cancer, primary vulvar cancer, or recurrent gynecological cancer - Your cancer is at FIGO stage I through IVA - Your general health is reasonably good (ECOG score 0–2) **You may NOT be eligible if...** - You are pregnant - There is a medical reason you cannot receive brachytherapy - You have inflammatory bowel disease, a history of bowel blockage, or abdominal adhesions - You have had a kidney transplant or have a horseshoe kidney - Your cancer has significantly invaded surrounding blood vessels or the pelvic walls - You need a more invasive type of internal radiation (interstitial implants) Talk to your doctor to see if this trial is right for you.