RecruitingNCT06464029

Pathways Mediating Impaired Postural Control in Parkinson's Disease

Sponsor

University of Minnesota

Enrollment

120 participants

Start Date

Jun 1, 2024

Study Type

OBSERVATIONAL

Conditions

Parkinson Disease

Summary

The purpose of this project is to use transcranial magnetic stimulation (TMS) to explore the state of excitability of corticocortical and corticofugal (cortex to spinal cord, cortex to brainstem to spinal cord) pathways that project to muscles that control the legs and trunk in people with Parkinson's disease. The outcome variables will be further analyzed to understand their relationship to quantitative measures of postural instability and gait dysfunction. As such, the project can be classified as basic physiologic research. The protocol is not designed to determine if measures of corticocortical or corticofugal excitability can be used as a biomarker to predict disease progression.

Eligibility

Min Age: 45 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating what happens in the brain and body that causes balance and posture problems in people with Parkinson's disease. Healthy older adults are also invited to participate as a comparison group. **You may be eligible if...** - You are between 45 and 80 years old - You have been diagnosed with Parkinson's disease or dystonia by a specialist (OR you are a healthy older adult for the control group) - You can walk at least 50 meters on your own without a cane or walker **You may NOT be eligible if...** - You cannot walk independently without an assistive device - You fall outside the 45–80 age range Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

University of Minnesota

Minneapolis, Minnesota, United States

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NCT06464029

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