RecruitingNot ApplicableNCT06510231

Inspiratory Muscle Training in HFpEF

Inspiratory Muscle Training in Heart Failure With Preserved Ejection Fraction

Sponsor

Mayo Clinic

Enrollment

68 participants

Start Date

Oct 9, 2024

Study Type

INTERVENTIONAL

Conditions

This study is being done to determine how inspiratory muscle training impacts inspiratory muscle function during exercise in heart failure patients.

Min Age: 18 Years

≥18 yrs of age
Receiving SGLT2 inhibitors and spironolactone (and beta-blocker use for HFpEF patients with hypertension) for \>3 months
NYHA symptoms I-III
Body mass index ≤40 kg/m2
Currently non-smokers with \<20 pack year history
Able to exercise (i.e. without significant orthopedic limitations or musculoskeletal disorders limiting their ability to exercise)

Sustained ventricular tachycardia and/or ventricular fibrillation within 21 days of visit 1
Second or third degree heart block
Body mass index \>40 kg/m2
Current smokers and/or smoking history \>20 pack years
Pregnant women (testing will be done by research team if requested)
Glomerular filtration rate of \<30 mL/min/1.73m2 (initial screen via clinical record within the past 6 months and this will be assessed on Visit 1)
Individuals who are not able to engage in exercise
Uremia, history of allergy to iodides
Peripheral artery disease
Alanine transaminase and/or aspartate transaminase greater than 2 times the upper limit of normal (via clinical record within the past 6 months)
Asthmatic patients with a low symptom perception and suffer frequency, severe exacerbations or with an abnormally low perception of dyspnea
Ruptured eardrum or any other condition of the ear
History of spontaneous pneumothorax or osteoporosis with a history of rib fractures
History of lidocaine allergy.

OTHERInspiratory Muscle Training

Inspiratory muscle training (IMT) targets the inspiratory muscles and is used to improve inspiratory muscle strength.

Mayo Clinic in Rochester

Rochester, Minnesota, United States

View Full Details on ClinicalTrials.gov

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NCT06510231