RecruitingPhase 4NCT06527560

Clinical Trial Comparing Oral Versus Intravenous Cefuroxime in Pregnant Women with Pyelonephritis


Sponsor

Hospital de Clinicas de Porto Alegre

Enrollment

100 participants

Start Date

Sep 9, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to compare rates of cure in pregnant women with pyelonephritis. The main question aims to answer: Can we treat pyelonephritis in pregnancy with oral cefuroxime alone? Pregnant women with pyelonephritis treated with intravenous cefuroxime will be the comparator. Participants will be asked to accept participation in the study and will be randomly allocated to one of the two arms: * Intravenous cefuroxime 750 mg every 8 hours + oral placebo every 12 hours * Oral cefuroxime 500 mg every 12 hours + intravenous saline solution every 8 hours


Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 48 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Cefuroxime and a drug called Cefuroxime Axetil for people with pyelonephritis in pregnancy. The study is currently recruiting participants at 1 location.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGCefuroxime

Intravenous cefuroxime 750 mg every 8 hours

DRUGCefuroxime Axetil

Oral cefuroxime 500 mg every 12 hours


Locations(1)

HCPA

Porto Alegre, Rio Grande do Sul, Brazil

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NCT06527560