Curcumin and EGCG Supplementation to Improve Serum BDNF and Mood Disturbance
A Randomized Controlled Trial to Determine the Effects of Curcumin and Epigallocatechin Gallate Supplementation on Serum Brain Derived Neurotrophic Factor and Mood Disturbance in Adults
Auburn University
64 participants
Sep 30, 2024
INTERVENTIONAL
Summary
The goal of this randomized placebo controlled trial is to examine mood disturbance and serum brain derived neurotrophic factor (BDNF) in people (age 18-50) with DASS-21 subscale scores \>9. The main questions it aims to answer are: Does curcumin and EGCG supplementation improve mood disturbance symptomology? Does curcumin and EGCG supplementation increase serum BDNF? Researchers will compare intervention versus placebo. Participants will consume an 8-week supplement of both: * 1,330mg/day curcumin * 350mg/day epigallocatechin gallate (EGCG)
Eligibility
Inclusion Criteria4
- Adults age 18-50
- Depression subscale score of >9/21 on the DASS-21
- No change in medications or supplements over the past 3 months
- Can read and speak English
Exclusion Criteria3
- Currently consume curcumin or green tea daily
- Currently, pregnant, nursing, or trying to become pregnant
- Currently diagnosed with a perimenopausal disorder
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Interventions
1,330 mg curcumin
350 mg Epigallocatechin gallate (EGCG)
Placebo to be consumed after randomization.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06531863