RecruitingNCT06535074

Lung Function Monitoring During Hypoxemia Episodes

Differentiating Pathophysiological Mechanisms of Hypoxemia Episodes by Continuous Lung Function Monitoring in Preterm Infants

Sponsor

Rutgers, The State University of New Jersey

Enrollment

35 participants

Start Date

Apr 4, 2024

Study Type

OBSERVATIONAL

Conditions

Hypoxemia of Newborn

Summary

Premature infants commonly have desaturation episodes due to different reasons such as cessation of breathing or loss of lung volume. The purpose of this study is to differentiate the mechanisms of desaturation episodes with continuous lung volume monitoring. As we better understand the mechanisms underlying the desaturation episodes, newer strategies directed at underlying pathophysiology can potentially by evaluated for mitigation of these episodes.

Eligibility

Plain Language Summary

Simplified for easier understanding

This study monitors lung function in premature babies who experience frequent drops in oxygen levels (called hypoxemia episodes) while in the hospital. Researchers want to understand how breathing patterns change during these oxygen dips to find better ways to help these vulnerable newborns. **You may be eligible if...** - Your baby was born at 32 weeks of pregnancy or earlier - Your baby's corrected age is between 30 and 36 weeks - Your baby has had 4 or more episodes of low oxygen in the past 24 hours **You may NOT be eligible if...** - Your baby has a major birth defect - Your baby is on an invasive breathing machine (mechanical ventilation) - Your baby has a serious brain injury - Your baby has unstable circulation requiring heart-supporting medications in the last 3 days Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERDetecting changes in lung volume with hypoxemia episodes

Electrical impedance tomography (EIT) will be used to assess changes in lung aeration prior and during hypoxemia episodes to classify them into four different subtypes. FE subtype: Defined as HEs preceded by reduction in EELI below the baseline. Apnea subtype: Defined as HEs not meeting the criteria for FE subtype and preceded by cessation of breathing. Mixed subtype: Defined as HEs meeting the criteria for both FE and apnea subtypes. Unclassified: Defined as HEs not categorized into any of the above parameters.

Locations(1)

Bristol Myers Squibbs Childrens Hospital

New Brunswick, New Jersey, United States

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NCT06535074