RecruitingNCT06585761

Effect of Sodium Glucose Co-tansporter 2 Inhibitors (SGLT2I) on Inflammatory and Oxidative Stress Markers Level in Heart Failure Patients


Sponsor

Kafrelsheikh University

Enrollment

60 participants

Start Date

Feb 15, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

The aim of this study is to explore the effect of SGLT2i on the levels of cardiac biomarkers, inflammatory and stress markers in Egyptian heart failure patients to provide a better understanding of mechanism that might assist in tailoring treatment strategies in patients with various forms of HF especially in Egyptian population. Also understand how biomarkers may be employed to predict risk in patients receiving SGLT2i or identification of those who may derive the most benefit from SGLT2i in the means of individualized medicine.


Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is examining how a class of diabetes medications called SGLT2 inhibitors (commonly used for heart failure and diabetes) affect inflammation and oxidative stress (cell damage from unstable molecules) in patients with heart failure. Researchers hope this will explain why these drugs improve heart failure outcomes. **You may be eligible if...** - You are 18 or older with heart failure rated Class II–IV by standard criteria (moderate to severe symptoms) - You are already on standard heart failure medications (such as ACE inhibitors, beta-blockers, or diuretics) - You are starting or already taking an SGLT2 inhibitor as part of your regular care **You may NOT be eligible if...** - You have type 1 diabetes - You have severe kidney disease - You are pregnant or planning to become pregnant - You have had a recent heart attack or major heart procedure - You are allergic to SGLT2 inhibitor medications Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGSGLT2 inhibitor

patients with HF are subjected to regular dose of SGLT2I member according to patient status.

DEVICEecho cardiogram

the patients are subjected to ECHO to determine their EF prior to and post the study


Locations(1)

Kafrelsheikh University Hospital

Kafr ash Shaykh, Egypt

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NCT06585761


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