RecruitingNCT06626685

Clonal Hematopoiesis of Indeterminate Potential in Heart Failure.

Clonal Hematopoiesis of Indeterminate Potential in Heart Failure - RICO-HF.

Sponsor

FROM- Fondazione per la Ricerca Ospedale di Bergamo- ETS

Enrollment

300 participants

Start Date

Mar 10, 2025

Study Type

OBSERVATIONAL

Conditions

Heart Failure

Summary

This study is part of the Rico Macro-Project, a multidisciplinary research program promoted by FROM in collaboration with the ASST-PG23 and ATS Bergamo, aiming to investigate the role of clonal hematopoiesis on inflammation, studying in depth the mechanisms underlying the inflammatory process to determine their correlation with some important pathologies in different clinical fields (Hematology, Cardiology, Neurology, Pneumology, Gastroenterology, and Diabetology, etc.). In this context, the prospective observational study RICO-HF is developed. The RICO HF is the first project focused on CHIP and inflammation in the area of Cardiology, specifically in HF.

Eligibility

Min Age: 18 Years

Inclusion Criteria3

consecutive patients admitted to the Cardiology Unit of the ASST Papa Giovanni XXIII Hospital, Bergamo for acute HF and patients attending the outpatient HF clinic of the same hospital for chronic HF
age \>18 years
written informed consent

Exclusion Criteria10

chronic therapy with anti-inflammatories, steroids, immunomodulators, immunosuppressants, chemotherapeuthic agents
previous heart transplant
cardiogenic shock or cardiac arrest
recent acute coronary syndrome (\<3 months)
current acute infection requiring specific treatment
overt MPNs
primary myelodysplastic syndromes
malignant cancers
non-cardiovascular co-morbidity reducing life expectancy to \< 1 year
any factor precluding 1-year follow-up

Interventions

OTHERClinical and instrumental examination

Each patient, consecutively afferent to the SC Cardiologia I of the ASST-PG23 in Bergamo with the diagnosis of acute or chronic HF, at enrollment will undergo to routine clinical and instrumental examination.