Zanubrutinib Plus Rituximab as Front-line Treatment for Mucosa-associated Lymphoid Tissue Lymphoma (MALT)
Zanubrutinib Plus Rituximab as Front-line Treatment for Mucosa-associated Lymphoid Tissue Lymphoma (MALT): a Single-arm, Open-label, Multicenter, Phase II Study（ZAMA）
Sun Yat-sen University
42 participants
Oct 30, 2024
INTERVENTIONAL
Conditions
Summary
This is a prospective, single-arm, multicenter, phase II clinical trial to evaluate the efficacy and safety of Zanubrutinib in combination with Rituximab as a first-line treatment for patients with mucosa-associated lymphoid tissue (MALT) extranodal marginal zone lymphoma.
Eligibility
Inclusion Criteria6
- Mucosa-associated lymphoid tissue (MALT) extranodal marginal zone lymphoma confirmed by histopathology.
- Newly diagnosed with Ann Arbor stage III-IV or relapsed MALT after local treatment .
- No prior systemic anti-lymphoma therapy (except for H. pylori eradication therapy in H. pylori-positive gastric MALT patients).
- No histopathological transformation to high-grade lymphoma.
- At least one measurable lesion according to the Lugano 2014 criteria.
- \. Age ≥ 18 years, with no gender restrictions. 7. An ECOG performance status score of 0-2. 8. An expected survival time of more than 12 months. 9. Adequate bone marrow, cardiac, pulmonary, liver, and kidney function. 10. Willing to participate in the clinical study; fully informed and aware of the study, having signed the informed consent form; willing and able to comply with all study procedures.
Exclusion Criteria10
- Patients with a history of stroke, intracranial hemorrhage, or warfarin use within the past 6 months.
- Patients with central nervous system involvement.
- Patients who have undergone allogeneic hematopoietic stem cell transplantation in the past.
- Patients who have previously used BTK inhibitors or received CD20 monoclonal antibody therapy.
- , Patients with active infections, except for tumor-related B-symptom fever. 6. Patients with a concurrent history of other malignancies, except for cured cervical carcinoma in situ or basal cell carcinoma of the skin.
- \. Patients receiving potent cytochrome P450 inhibitors. 8. Patients with severe cardiovascular diseases, such as uncontrolled or symptomatic arrhythmias, congestive heart failure, or a history of myocardial infarction within the past 12 months.
- \. Patients, as judged by the investigator, who have significant organ dysfunction or uncontrollable comorbidities that pose a safety risk, or who have absorption and metabolism issues with Zanubrutinib.
- \. Pregnant or breastfeeding women and women of childbearing age unwilling to use contraception.
- \. Patients who have received anti-tumor therapy within 4 weeks prior to enrollment.
- \. Patients with active chronic hepatitis B or active hepatitis C. 13. Patients who have received systemic corticosteroid treatment or other immunosuppressive therapy within 14 days prior to the start of study treatment.
Interventions
160 mg, administered twice daily from Day 1 to Day 28 (D1-D28)
375 mg/m², administered once a week during Cycle 1 (C1), and on Day 1 (D1) of Cycles 2-6 (C2-C6)
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06647732