MethMax Trial: MAXimising the METHotrexate Therapy Potential in Patients with Active Rheumatoid Arthritis

This study is testing whether giving methotrexate — a common rheumatoid arthritis (RA) medication — by injection instead of as a pill, and at a higher dose, works better for people whose RA is not fully controlled on their current oral dose. **You may be eligible if...** - You are 18 or older with a confirmed diagnosis of rheumatoid arthritis - You are already taking oral methotrexate (10–25 mg per week) for at least 3 months - Your RA is still active — your joints are not well controlled and you have at least one swollen joint - You are willing to increase the dose and switch to injectable methotrexate as part of the study **You may NOT be eligible if...** - You have serious liver, kidney, or lung problems - You are pregnant or planning to become pregnant - You have had serious infections recently - You are already on other biologic or advanced RA therapies Talk to your doctor to see if this trial is right for you.