Intravascular Radiofrequency Ablation of Sympathetic Nerves for the Treatment of Hepatocellular Carcinoma

This study is testing a minimally invasive procedure that uses radiofrequency energy delivered inside blood vessels to disrupt (ablate) sympathetic nerves near the liver — nerves that may be driving tumor growth — as a potential treatment for advanced liver cancer (hepatocellular carcinoma, or HCC) that has not responded to previous therapies. **You may be eligible if...** - You have been diagnosed with hepatocellular carcinoma (liver cancer), confirmed clinically or by biopsy - Your cancer is locally advanced or has spread to other parts of the body and cannot be surgically removed - Your cancer has progressed after at least two lines of prior treatment - You are willing to sign the consent form and participate **You may NOT be eligible if...** - You are not a surgical candidate for ablation - You are pregnant, breastfeeding, or planning to become pregnant - You have low blood pressure when standing (orthostatic hypotension) - You have a mixed type of liver cancer - You have intestinal obstruction, bleeding problems, or blood disorders - You have had a recent stroke or heart attack (within the last two weeks) Talk to your doctor to see if this trial is right for you.