RecruitingPhase 1NCT06732492

RD13-02 Cell Injection in Patients with Relapsed or Refractory CD7-Positive Natural Killer/T Cell Malignancies


Sponsor

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Enrollment

10 participants

Start Date

Oct 31, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This is a single-arm, open-label, single-center, phase I study. The primary objective is to evaluate the safety of CD7 Chimeric Antigen Receptor-T(CAR-T) therapy for patients with CD7-positive relapsed or refractory natural killer/T cell lymphoma, and to evaluate the pharmacokinetics of CD7 CAR-T in patients。


Eligibility

Min Age: 3 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new cell therapy called RD13-02 — a type of engineered immune cell treatment that targets the CD7 protein — for people with a rare and aggressive blood cancer called NK/T cell lymphoma or leukemia that has come back or stopped responding to treatment. **You may be eligible if...** - You are 3–70 years old - You have been diagnosed with relapsed or refractory NK/T cell lymphoma that carries the CD7 protein marker - Your bone marrow contains at least 5% lymphoma cells - Your heart, kidney, liver, and lung function are adequate - Your expected survival is at least 3 months - You or your legal guardian can give informed consent **You may NOT be eligible if...** - You have a genetic syndrome associated with immune deficiency - Your heart is pumping at less than 50% efficiency - You have severe organ dysfunction - You are pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGRD13-02 cell infusion

CAR-T cells


Locations(1)

Union Hospital

Wuhan, Hubei, China

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06732492


Related Trials