Study on the Value of Three DWI Scanning Sequences in Staging of Gastric Cancer
Comparative Study on the Value of Three DWI Scan Sequences of 3.0T Magnetic Resonance in Staging of Gastric Cancer
Yunnan Cancer Hospital
129 participants
Dec 23, 2023
INTERVENTIONAL
Conditions
Summary
Accurate staging is critical for effective gastric cancer treatment planning. Conventional DWI (C-DWI) has limitations in image quality due to magnetic field inhomogeneity, which hampers precise T staging. This study aims to compare the image quality and T staging accuracy of C-DWI, TSE-DWI, and ZOOMit-DWI (Z-DWI) sequences in MRI examinations of gastric cancer patients. A prospective study plan to enroll 72 gastric cancer patients undergoing preoperative MRI with C-DWI, TSE-DWI, and Z-DWI sequences using a 3.0 T scanner. Quantitative metrics (ADC, SNR, CNR) and image quality were evaluated. T staging accuracy was assessed by comparing MRI results with postoperative pathological staging using ROC analysis.
Eligibility
Inclusion Criteria3
- The patient was diagnosed with gastric cancer by pathological biopsy
- No biopsy was taken within 1 week before MR Examination to rule out the effect of bleeding on the image
- No contraindications for MRI examination; And exclude serious heart, liver, kidney, cerebrovascular diseases.
Exclusion Criteria2
- The image quality cannot meet the diagnostic criteria;
- Patients could not tolerate MRI examination, resulting in incomplete MR-related sequence image data.
Interventions
Based on abdominal scanning, TSE-DWI,ZOOMIT DWI and EPI-DWI scans were performed, and the study was divided into two steps according to the nanomotion criteria. The first step was self-controlled, which was divided into experimental group and control group. The experimental group included TSE-DWI,ZOOMit DWI, and the control group included EPI-DWI. Then the image quality was evaluated by subjective and objective evaluation indexes. In the second step, the three DWI stages were performed separately by four diagnosticians, with an interval of 1 month, and statistical analysis was performed at the end.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06735105