ClinicalTrialsFinder
RecruitingNot ApplicableNCT06753409

Processed Electroencephalography-guided General Anesthesia and Outcomes in Major Abdominal Surgery

Impact of Reduced Intraoperative Norepinephrine Requirements Via Processed Electroencephalography-Guided General Anesthesia on Patient Outcomes After Major Abdominal Surgeries

Sponsor

Assiut University

Enrollment

162 participants

Start Date

Feb 1, 2025

Study Type

INTERVENTIONAL

Conditions

Postoperative Acute Kidney Injury

Summary

This study aims to evaluate whether the reduction in the amount of intraoperative norepinephrine required to prevent hypotension, facilitated by processed electroencephalography (pEEG) -guided general anesthesia, will lead to a decrease in postoperative complications, particularly acute kidney injury (AKI).

Eligibility

Min Age: 18 YearsMax Age: 70 Years

Inclusion Criteria4

  • Patients scheduled for major abdominal surgery lasting more than 2 hours under general anesthesia.
  • American Society of Anesthesiologists Physical Status (ASA) score I-III.
  • Age range of 18-70 years.
  • Both male and female patients.

Exclusion Criteria8

  • Emergency surgeries.
  • Uncontrolled hypertension (systolic blood pressure \>150 mm Hg) despite medication.
  • Recent acute cardiovascular events, including heart failure or acute coronary syndrome.
  • Chronic kidney disease with a glomerular filtration rate \<30 ml/min/1.73 m² or requiring renal replacement therapy.
  • Severe hepatic failure (ASAT/ALAT \>2N, elevated bilirubin, or PT \<50%).
  • Preoperative sepsis or septic shock.
  • Pregnancy.
  • Patient refusal to participate in the study.
Print for Your Doctor

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DEVICEProcessed electroencephalography (pEEG) Guided General Anesthesia

Processed electroencephalography (pEEG) can guide the optimization of anesthesia depth, potentially preventing overly deep anesthesia and, in turn, reducing the incidence of IOH and the need for vasopressors . Depth of anesthesia will be managed based on pEEG monitoring using Entropy with a target range of 40-60.

DEVICENon-pEEG-Guided General Anesthesia (with blinded pEEG monitoring)

Depth of anesthesia will be managed based on clinical judgment, informed by clinical perception and vital signs.

Locations(1)

Assiut University Hospitals

Asyut, Egypt

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06753409

Related Trials

The Relationship Between Preoperative Frailty and Postoperative AKI and the Mediating Effect of Intraoperative BP

NCT070301791 location