Intraperitoneal Immune Checkpoint Inhibitors and Zoledronic Acids for Gastric Cancer Malignant Ascites

This study is testing whether injecting immune checkpoint inhibitors and zoledronic acid (a bone-strengthening drug) directly into the abdominal cavity can help control malignant ascites — a build-up of fluid in the belly caused by stomach cancer that has spread. **You may be eligible if...** - You are between 18 and 75 years old - You have gastric (stomach) adenocarcinoma confirmed by biopsy - You have malignant ascites (fluid in your belly caused by cancer) confirmed by fluid analysis and CT scan - You are in reasonably good health (Karnofsky score of 70 or above) with at least 3 months expected survival - You have adequate blood count, liver, kidney, and clotting function **You may NOT be eligible if...** - Your fluid build-up is not cancer-related (e.g., from liver disease) - You have conditions that prevent immunotherapy use (such as autoimmune disease or long-term steroid use) - You are pregnant or breastfeeding - You have severe abdominal scarring or bowel blockage history - You are in another clinical trial Talk to your doctor to see if this trial is right for you.