Sarcopenia and Systemic Therapy in HCC

This study is investigating whether low muscle mass (sarcopenia) affects how well people with liver cancer (hepatocellular carcinoma) respond to targeted drug treatments (TKIs), and how it influences their overall outcomes. **You may be eligible if...** - You are 18 or older - You have been diagnosed with hepatocellular carcinoma (liver cancer) confirmed by imaging or biopsy - You have intermediate or advanced liver cancer, or early-stage cancer that has not responded to previous local treatments - You are being treated with targeted cancer drugs called TKIs (tyrosine kinase inhibitors) as recommended by your doctors - You had a CT scan within 8 weeks before starting TKI therapy **You may NOT be eligible if...** - There are no additional exclusion criteria listed for this study Talk to your doctor to see if this trial is right for you.