Prediction of Blood Pressure Outcomes Following Renal Denervation (PREDICT-RDN)
Heart Center Leipzig - University Hospital
90 participants
Jun 1, 2025
INTERVENTIONAL
Conditions
Summary
Prospective, single arm trial to assess the effects of renal denervation on day-by-day blood pressure measurements and time in blood pressure target range, as well as establish a multivariate prediction model for blood pressure reduction after renal denervation.
Eligibility
Inclusion Criteria4
- Confirmed arterial hypertension with systolic or diastolic blood pressure \>140/90 mmHg in standardized office blood pressure measurement
- Treatment with 3 to ≤5 antihypertensive drug classes
- Age \>18 years
- Written informed consent
Exclusion Criteria5
- Age ≤ 18 years
- anatomy unsuitable for renal denervation (i.e. renal artery stenosis, single functioning kidney)
- pregnancy
- patients under legal supervision or guardianship
- participation in other trials that might interfere with the study outcome according to the opinion of one of the investigators.
Interventions
All procedures will be carried out by highly experienced interventional cardiologists, each having performed a minimum of 20 RDN prior to treating study patients. All interventions will be performed with the CE-marked Symplicity SpyralTM (Medtronic, Minneapolis, MN, USA) renal denervation system following current treatment standards. Procedures will be performed as stated in the IFU. The specific ablation points will be determined by the discretion of the interventionalist.
Locations(2)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06845579