RecruitingNCT06877637

On-treatment Surveillance of Tumor Evolution and Response to Systemic Treatment in Bile Duct and Liver Cancer

BILe Duct and LIver Cancer: ON-treatment Surveillance of Tumor Evolution And Response to Systemic Treatment

Sponsor

Region Skane

Enrollment

150 participants

Start Date

May 15, 2025

Study Type

OBSERVATIONAL

Conditions

Cholangiocarcinoma Hepatocellular Carcinoma (HCC)

Summary

The BILLIONSTARS study is a prospective, single arm observational study inviting patients diagnosed with hepatocellular carcinoma (HCC) or cholangiocarcinoma (CCC) who are to be recommended locoregional intervention by surgery, ablation or transarterial chemoembolization and/or antitumoral medical treatment. The aim is to investigate how tumor- and individual-related factors affect response to treatment. To this end, circulating tumor DNA, immune cells and various proteins will be analyzed in repeated blood samples taken before, during and after completion of systemic treatment. When applicable, analyses will also be performed on tumor tissue from resected tumors and biopsies, and in some cases also from autopsies

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is collecting blood samples and tissue over time from patients with bile duct cancer (cholangiocarcinoma), gallbladder cancer, or liver cancer (hepatocellular carcinoma) to track how their cancer evolves during treatment using liquid biopsy techniques. **You may be eligible if...** - You are over 18 years old - You have a clinical or confirmed diagnosis of intrahepatic, perihilar, or distal cholangiocarcinoma, gallbladder carcinoma, mixed liver-bile duct cancer, or hepatocellular carcinoma - You are planned to undergo surgery, ablation, or a procedure called TACE (a targeted liver treatment), or are receiving palliative (non-curative) systemic therapy **You may NOT be eligible if...** - You are 18 or younger - You are unable to give informed consent - Your cancer type or treatment plan does not match the study requirements Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.