RecruitingPhase 2NCT06932757
Adjuvant Quisinostat in High-Risk Uveal Melanoma
Phase 2 Trial of Adjuvant Quisinostat in High-Risk Uveal Melanoma
Sponsor
University of Miami
Enrollment
63 participants
Start Date
May 27, 2025
Study Type
INTERVENTIONAL
Conditions
Summary
The purpose of this study is to see if giving participants quisinostat will prevent participants' uveal melanoma tumor from spreading. The researchers want to find out the effects that quisinostat has on participants' condition.
Eligibility
Min Age: 19 Years
Plain Language Summary
Simplified for easier understanding
This trial is studying a drug called quisinostat as an additional (adjuvant) treatment after primary therapy for uveal melanoma — a rare type of eye cancer — in patients considered high-risk for the cancer coming back. Quisinostat works by blocking enzymes that help cancer cells survive.
**You may be eligible if...**
- You have been diagnosed with uveal melanoma (melanoma of the eye)
- Your cancer is considered high-risk — meaning it has features likely to spread
- You have completed your primary eye treatment (such as radiation or surgery)
- You are an adult in adequate overall health
**You may NOT be eligible if...**
- Your cancer has already spread to other parts of the body (distant metastases)
- You have serious heart rhythm abnormalities (QT prolongation)
- You have significant liver or kidney problems
- You are pregnant or breastfeeding
- You have uncontrolled infections or other serious illnesses
Talk to your doctor to see if this trial is right for you.
This is a simplified summary. Always discuss eligibility with your doctor before enrolling in a clinical trial.
Interventions
DRUGQuisinostat
Participants will receive 12 mg of Quisinostat via capsule to be taken orally three times per week of each 21 day cycle.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06932757
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