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RecruitingNot ApplicableNCT06966674

No-Reflow in Patients With STEMI After Intracoronary Tirofiban After Opening of the Track

Assessment of No-Reflow in Patients With STEMI After Intracoronary Tirofiban After Opening of the Track

Sponsor

Kafrelsheikh University

Enrollment

60 participants

Start Date

May 12, 2025

Study Type

INTERVENTIONAL

Conditions

STEMINo-ReflowIntracoronaryTirofiban

Summary

This study aims to assess the no-reflow in patients with STEMI after intracoronary glycoprotein IIb/IIIa inhibitors after opening of track in thrombus.

Eligibility

Min Age: 18 Years

Inclusion Criteria3

  • Age ≥ 18 years old.
  • Both sexes.
  • Patients with STEMI. ST-segment elevated myocardial infarction is defined as typical chest pain \>30 minutes with ST-segment elevation of \>1 mm in at least 2 consecutive leads on the electrocardiogram or new-onset left bundle brunch block.

Exclusion Criteria7

  • Treatment with thrombolytic drugs in the previous 24 hours.
  • Known malignancy.
  • Thrombocytopenia.
  • End-stage liver disease.
  • Cardiogenic shock.
  • Renal failure with glomerular filtration\<30 ml/min.
  • Contraindication for the use of tirofiban.
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Interventions

DRUGIntracoronary tirofiban

Patients will receive intracoronary tirofiban (Aggrastat®) (25 mg/kg).

DRUGSaline 0.9%

Patients will receive intracoronary saline 0.9% solution as a control group.

Locations(1)

Kafrelsheikh University

Kafr ash Shaykh, Kafrelsheikh, Egypt

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NCT06966674

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