RecruitingNot ApplicableNCT06994065

Efficacy of Ferric Carboxymaltose Versus Iron Sucrose in Non-dialysis Dependent Chronic Kidney Disease Patients


Sponsor

Sindh Institute of Urology and Transplantation

Enrollment

128 participants

Start Date

Jun 2, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to learn if Ferric Carboxymaltose is a safe efficacious alternative to Iron Sucrose for treatment of Iron deficiency anemia in non-dialysis dependent chronic kidney disease patients. The main questions it aims to answer are: * Does Ferric Carboxymaltose causes similar or higher rise in hemoglobin concentration and serum Ferritin and transferrin saturation * What medical problems will participants have when receiving Ferric Carboxymaltose Participants will: * Be administered either Ferric Carboxymaltose or Iron Sucrose * Visit the clinic at day 28 and 56 for checkup and tests * Be monitored for any medical problem during and after infusion


Eligibility

Min Age: 18 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study is comparing two types of intravenous iron treatment — ferric carboxymaltose and iron sucrose — to see which is more effective and better tolerated in people with chronic kidney disease who have iron deficiency anemia and are not yet on dialysis. **You may be eligible if...** - You are an outpatient aged 18–85 - You have chronic kidney disease with a kidney filtration rate below 60 mL/min and are not on dialysis - You have iron deficiency anemia **You may NOT be eligible if...** - You are on maintenance dialysis - You have a vitamin B12 or folate deficiency - You are receiving erythropoiesis-stimulating agents (ESA) - You have received iron therapy in the past 2 weeks or blood transfusions in the past 3 months - You are pregnant - You have active bleeding from the upper digestive tract, a blood disorder, active cancer, or chronic inflammatory conditions like tuberculosis or ulcerative colitis Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGFerric Carboxymaltose (FCM)

This study will dose each patient according to their calculated iron deficit through Ganozi formula Iron deficit(mg) = bodyweight(kg) x (target Hb - actual Hb) (g/dl) x 2.4 + Iron storage depot(mg)

DRUGIron Sucrose injection

This study will dose each patient according to their calculated iron deficit through Ganozi formula Iron deficit(mg) = bodyweight(kg) x (target Hb - actual Hb) (g/dl) x 2.4 + Iron storage depot(mg)


Locations(1)

Sindh Institute of Urology and Transplantaion

Karachi, Sindh, Pakistan

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NCT06994065