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RecruitingNot ApplicableNCT06995040

BREMISS : Brain Resilience Minor Stroke Study

Initial Predictors of Long-term Brain Resilience After Minor Ischemic Stroke: a Study Nested in the Brest Stroke Population-based Registry

Sponsor

University Hospital, Brest

Enrollment

1,000 participants

Start Date

Jun 18, 2025

Study Type

INTERVENTIONAL

Summary

The objective of this clinical trial is to develop, based on patients' initial characteristics (in the first few weeks following the stroke), a predictive model of quality of life more than 4 years after the stroke in patients who have suffered a minor ischemic stroke. The main question it aims to answer is: \- Is it possible to predict the quality of life of patients who have suffered a minor ischemic stroke based on their initial characteristics? To do this, retrospective and prospective data collected as part of the study will be analyzed using a conventional statistical approach and algorithms based on AI approaches in order to create a predictive model. Participants will be asked to: * Complete questionnaires * Provide a saliva sample (optional) * Undergo an MRI scan (optional)

Eligibility

Min Age: 18 Years

Inclusion Criteria8

  • Cases of stroke in the Brest Stroke Registry (BSR)
  • Ability to sign informed consent
  • Patients followed-up > 4 years during the study period
  • NIHSS score ≤ 5 on admission
  • First stroke above 18 and before 75-year old
  • Rankin before stroke < 1
  • Possibility to draw saliva samples for genomic study
  • Possibility to perform Cerebral MRI

Exclusion Criteria5

  • Patients with transient neurological deficits resolving within one hour and normal brain imaging will be excluded.
  • Not affiliated to social security
  • Patient under legal protection or deprived of liberty by a judicial or administrative decision
  • Patient unable to sign informed consent
  • Patient whose follow-up will be impossible

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Interventions

DIAGNOSTIC_TESTCerebral MRI without contrast agent injection

Cerebral MRI at inclusion or after

GENETICsaliva sample

Saliva sample for DNA analysis at inclusion or send to their home.

OTHERQuestionnaires

Quality of life and cognitive questionnaires at inclusion

Locations(1)

CHU de Brest

Brest, France

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NCT06995040