RecruitingNot ApplicableNCT07000994

Dobutamine During Major Abdominal Surgery

Dobutamine During Major Abdominal Surgery: A Randomized Pilot Trial (PUSH-1)

Sponsor

University of Hamburg-Eppendorf

Enrollment

100 participants

Start Date

Jun 16, 2025

Study Type

INTERVENTIONAL

Conditions

Intraoperative Myocardial Depression

Summary

The PUSH-1 trial is a randomized, single-center pilot trial investigating whether dobutamine administration is feasible in patients having major abdominal surgery.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether giving the heart medication dobutamine during major abdominal surgery can help protect organs and improve recovery. Researchers will monitor heart and circulation closely throughout the procedure. **You may be eligible if...** - You are 18 or older - You are scheduled for a planned (non-emergency) major abdominal surgery under general anesthesia that is expected to last at least 2 hours - You will already have an arterial line (a thin tube in an artery) placed during surgery for routine blood pressure monitoring **You may NOT be eligible if...** - Your surgery is an emergency - You are having a liver or kidney transplant, or have previously had a transplant - You are pregnant - You have an abnormal heart rhythm (anything other than normal sinus rhythm) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGDobutamine

In patient assigned to dobutamine administration, dobutamine (concentration: 5 mg mL-1) will be administered with an infusion rate of 3 µg kg-1 min-1 (ideal body weight).

OTHERRoutine care

In patients assigned to routine care, intraoperative hemodynamic management will be in accordance with routine care.

Locations(1)

University Medical Center Hamburg-Eppendorf

Hamburg, Free and Hanseatic City of Hamburg, Germany

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NCT07000994