RecruitingNot ApplicableNCT07002073

Comparison of the Hemodynamic Effects of Ketamine - Dexmedetomidine (Ketodex) Versus Propofol-ketamine Admixture (Ketofol) During Induction of Anesthesia in Elderly: A Randomized Comparative Study

Sponsor

Kasr El Aini Hospital

Enrollment

102 participants

Start Date

Jan 1, 2025

Study Type

INTERVENTIONAL

Conditions

Ketamine-dexmedetomidine Induction of Anesthesia

Summary

To compare the hemodynamic effects of Ketamine-Dexmedetomidine admixture (Ketodex) versus propofol-ketamine admixture (Ketofol) during induction of anesthesia in elderly

Eligibility

Min Age: 65 Years

Inclusion Criteria3

Elderly patients (\>65 years)
ASA physical status I-III
Elective non-cardiac surgery under general anesthesia.

Exclusion Criteria7

Patients with severe cardiac morbidities (impaired contractility with ejection fraction \< 50%, heart block, arrhythmias, tight valvular lesions, metabolic equivalent \[MET\] less than 4
Patients on angiotensin-converting enzyme inhibitors and angiotensin receptor blockers medications
Patients with uncontrolled hypertension
patients undergoing adrenalectomy
patients with body mass index \<18 or \> 35 kg/m²
patient with allergy to any of the study drugs.
patient is considered to be a difficult intubation in the preoperative assessment.

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Interventions

DRUGIntravenous Induction of Anesthesia

To compare incidence of hypotension following ketodex versus ketofol during intavenous induction of general anesthesia in elderly patients

Locations(1)

Cairo University Hospitals

Cairo, Giza Governorate, Egypt

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NCT07002073