RecruitingNCT07019844

PSMA PET for the Staging and Management of Hepatocellular Carcinoma

Addition of F18-Piflufolastat PET/CT to Cross-Sectional Imaging for the Staging and Management of Hepatocellular Carcinoma

Sponsor

VA Office of Research and Development

Enrollment

90 participants

Start Date

Sep 19, 2024

Study Type

OBSERVATIONAL

Conditions

Hepatocellular Carcinoma (HCC)

Summary

This prospective, single-center study evaluates the clinical utility of F18-Piflufolastat (PSMA) PET/CT when added to conventional cross-sectional imaging for patients with suspected or confirmed hepatocellular carcinoma (HCC). The study aims to determine whether PSMA PET/CT improves diagnostic accuracy for indeterminate liver lesions (LI-RADS 3 and 4), enhances staging precision in treatment-naïve patients, and provides more accurate assessment of treatment response in patients undergoing locoregional therapy (LRT). The goal is to assess how PSMA PET/CT may impact clinical decision-making, staging, and management of HCC across multiple stages of disease.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is evaluating a new type of imaging scan (PSMA PET scan) to better stage and guide treatment decisions in patients with liver cancer (hepatocellular carcinoma, or HCC) at VA medical centers. **You may be eligible if...** - You are an adult (18+) receiving care within the VA medical system - You have been newly diagnosed with HCC at an intermediate or advanced stage (BCLC stage B or C) and have not yet received treatment **You may NOT be eligible if...** - You have kidney problems or a contrast dye allergy that prevents you from having a standard CT scan with contrast - You have had another active cancer (other than HCC or non-melanoma skin cancer) in the past 3 years Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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