RecruitingPhase 1NCT07044271
A Study of Multiple Olomorasib (LY3537982) Capsules in Healthy Participants
An Open-Label, Randomized, 3-Way Crossover Study Comparing the Pharmacokinetics of Multiple Olomorasib (LY3537982) Capsules
Sponsor
Eli Lilly and Company
Enrollment
120 participants
Start Date
Jul 11, 2025
Study Type
INTERVENTIONAL
Conditions
Summary
The main purpose of this study is to measure how much olomorasib gets into the bloodstream and how long it takes the body to get rid of it. Healthy participants will take olomorasib by mouth. The study will last about 7 weeks and will include 10 back-to-back overnight stays in the research center.
Eligibility
Min Age: 18 YearsMax Age: 55 Years
Inclusion Criteria3
- Healthy status as defined by the absence of evidence of any clinically significant active or chronic disease
- Body mass index (BMI): 18.0 to 30.0 kilograms per square meter (kg/m²), inclusive
- Participants assigned male at birth (AMAB) or assigned female at birth (AFAB) who are individuals not of childbearing potential (INOCBP).
Exclusion Criteria3
- Females who are lactating or of childbearing potential
- Clinically significant history of any drug sensitivity, drug allergy, or food allergy
- Have used or plan to use medication within 14 days or 5 half-lives, whichever is longest, prior to admission, with the exception occasional acetaminophen at doses less than or equal to 2 g/day.
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Interventions
DRUGOlomorasib
Single dose
Locations(2)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07044271
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