The Epidemiology and Pathophysiology of Kidney Disease in HFpEF With Obesity

This study explores how the kidneys are affected by obesity and a specific type of heart failure called HFpEF (heart failure with preserved ejection fraction, meaning the heart pumps normally but is stiff). It includes three groups of people — healthy adults, people with obesity but no heart failure, and people with obesity and HFpEF — to compare how kidney function and structure differ across these groups. **You may be eligible if (Healthy group):** - You are between 18 and 75 with normal kidney function, no heart failure, and a BMI of 25–30 **You may be eligible if (Obese without heart failure):** - You are between 18 and 75 with a BMI above 35 and adequate kidney function (eGFR ≥ 60) **You may be eligible if (Obese with HFpEF):** - You are between 18 and 75 with a BMI above 35, adequate kidney function, and a confirmed diagnosis of HFpEF based on heart imaging and scoring **You may NOT be eligible if:** - You have serious chronic illness, cancer history, advanced kidney or liver disease - You are pregnant or breastfeeding - You are allergic to iodine-based contrast dye - You have very low hemoglobin, an acute illness, or were recently hospitalized - You currently use nicotine, recreational drugs, or drink heavily - You cannot stop taking NSAIDs (anti-inflammatory pain medications) during the study Talk to your doctor to see if this trial is right for you.