RecruitingNot ApplicableNCT07090096

A Randomized Controlled Trial of a Nutritional Intervention for Endometriosis

Sponsor

University of California, San Diego

Enrollment

120 participants

Start Date

Nov 1, 2025

Study Type

INTERVENTIONAL

Conditions

Endometriosis

Summary

This randomized, controlled study will investigate the efficacy of a dietary intervention for women with endometriosis. Participants will be randomly assigned to follow a whole food plant-based (intervention) diet or stay on their usual (control) diet for 12 weeks.

Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 45 Years

Inclusion Criteria8

Provision of signed and dated informed consent form
Stated willingness to comply with all study visits, procedures, requirements, and availability for the duration of the study
Women with a surgical, imaging, or clinical diagnosis of endometriosis
Age 18-45 years
Stable health condition and medications for the past 3 months
Modified Biberoglu and Behrman (B\&B) pelvic pain score of at least 5/9
Willing to be randomly assigned to either an active or a control group
Agreement to adhere to Lifestyle Considerations throughout the study duration

Exclusion Criteria8

Smoking or drug abuse during the past six months
Alcohol consumption of more than 2 drinks per day or the equivalent, episodic increased drinking (e.g., more than 2 drinks per day on weekends), or a history of alcohol abuse or dependency followed by any current use
Already following a WFPB diet
Pregnant or breastfeeding, or plans of pregnancy within the study period
Hysterectomy or ovariectomy
Fibroids, ovarian cysts, pelvic inflammatory disease
Endocrine inflammatory conditions, such as Cushing's syndrome, Hashimoto's thyroiditis, Graves' disease, type 1 diabetes mellitus, and Addison's disease
Evidence of an eating disorder