A Trial of SHR-1905 in Subjects With Severe Uncontrolled Asthma

This study is testing a new biologic drug called SHR-1905 for adults with severe asthma that is not controlled despite already taking medium-to-high doses of inhaled steroids plus at least one other controller medication. Researchers want to see if SHR-1905 reduces asthma attacks and improves breathing. **You may be eligible if...** - You are 18 or older - You have had a confirmed asthma diagnosis for at least 12 months - You have been on medium-to-high dose inhaled steroids for at least 6 months plus another asthma controller medication - You have had at least 2 asthma attacks requiring treatment in the past year - Your breathing test (FEV1) is below 80% of what's expected - Your asthma control questionnaire score is 1.5 or higher **You may NOT be eligible if...** - You have another significant lung disease (besides asthma) - You have had cancer - You smoke or have a significant smoking history (10+ pack-years) - You have hepatitis B, C, or HIV - You are pregnant or breastfeeding - You have had a severe allergic reaction to a biologic drug Talk to your doctor to see if this trial is right for you.