RecruitingPhase 1NCT07114367

NB02(POSELTINIB) Monotherapy in R/R Non-Hodgkin's Lymphoma

An Open-Label, Multicenter, Monotherapy, Dose-Escalation, Phase 1 Clinical Trial of NB02 (Posseltinib) in Patients With Relapsed/Refractory Non-Hodgkin's Lymphoma


Sponsor

NOBO Medicine

Enrollment

9 participants

Start Date

Dec 2, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This trial is an open-label, multicenter, monotherapy, dose-escalation, phase 1 clinical trial to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary anti-tumor activity of NB02 (posseltinib) in patients with relapsed/refractory NHL including FL, MCL and MZL


Eligibility

Min Age: 19 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This trial tests a drug called poseltinib (NB02) — a targeted oral therapy that blocks a protein called BTK — in people with certain types of slow-growing lymphoma (a blood cancer) that has come back or stopped responding to previous treatments. **You may be eligible if...** - You are 19–80 years old - You have been diagnosed with follicular lymphoma, mantle cell lymphoma, or marginal zone lymphoma - Your lymphoma has relapsed or stopped responding to at least 2 prior treatment regimens - You are reasonably functional (ECOG score 0–2) **You may NOT be eligible if...** - You have previously been treated with poseltinib or another BTK inhibitor (such as ibrutinib, acalabrutinib, or zanubrutinib) and your disease progressed on it - You cannot swallow oral medication - You have active HIV, hepatitis B, or hepatitis C - You were enrolled in another clinical trial within the past 4 weeks Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGNB02 (Poseltinib)

Dose Level 1, Dose Level 2, Dose Level 3


Locations(6)

Chonnam National University Hwasun Hospital

Hwasun, South Korea

Seoul National University Bundang Hospital

Seongnam, South Korea

Catholic univ of Yeouido St Mary's Hospital

Seoul, South Korea

Samsung Medical Center

Seoul, South Korea

Seoul National University Hospital

Seoul, South Korea

Ulsan University Hospital

Ulsan, South Korea

View Full Details on ClinicalTrials.gov

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NCT07114367


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