Post-stroke Pain tAN-fMRI
Investigating the Feasibility, Efficacy, and Renormalization of Pain-Regulation Brain Circuits Underlying At-Home Transcutaneous Auricular Neuromodulation (tAN) for Managing Chronic Post-Stroke Pain
Medical University of South Carolina
24 participants
Jan 8, 2026
INTERVENTIONAL
Conditions
Summary
The purpose of this study is to explore whether 4 weeks of at-home transcutaneous auricular neurostimulation (tAN) can reduce chronic pain after a stroke. Investigators will recruit up to 24 participants with chronic post-stroke upper extremity pain. The goal is to determine if there is a pain reduction after ear stimulation.
Eligibility
Inclusion Criteria3
- Age 18-80
- Have the capacity and ability to provide one's own consent in English and sign the informed consent document.
- Ischemic or hemorrhagic stroke that occurred at least 6 months prior
Exclusion Criteria6
- Primary intracerebral hematoma or subarachnoid hemorrhage
- Documented history of dementia
- Documented history of uncontrolled depression or psychiatric disorder
- Uncontrolled hypertension despite treatment, specifically SBP (Systolic Blood Pressure) / DBP (Diastolic Blood Pressure) \>=180/100mmHg
- Contraindicated for MRI scanning
- Pregnancy
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Interventions
Transcutaneous Auricular Neurostimulation (tAN) is a wearable, electrical stimulation device that delivers electricity to specific parts of the human ear.
Locations(2)
View Full Details on ClinicalTrials.gov
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NCT07144436