Cuff Pressure and Airway Edema in CABG With CPB
Effects of Endotracheal Tube Cuff Pressure Management on Upper Airway Edema During Cardiopulmonary Bypass in Coronary Artery Bypass Grafting: A Double-Blind, Randomized Controlled Trial
Engin Çetin
76 participants
Sep 24, 2025
INTERVENTIONAL
Conditions
Summary
This study investigates how endotracheal tube (ETT) cuff pressure management during cardiopulmonary bypass (CPB) in coronary artery bypass grafting (CABG) affects upper airway edema. Patients will be randomized into two groups: cuff pressure kept at 0 mmHg or maintained at 20-30 mmHg during CPB. Ultrasonography will be used to measure lateral pharyngeal wall thickness, tongue parameters, and other airway dimensions at predefined perioperative time points. The primary outcome is the change in lateral pharyngeal wall thickness as an indicator of airway edema. A total of 76 patients aged 18-80 years undergoing elective CABG with CPB will be enrolled. The results aim to clarify safe cuff pressure management strategies to reduce airway edema.
Eligibility
Inclusion Criteria4
- Patients scheduled for elective coronary artery bypass grafting (CABG) surgery
- Aged 18-80 years
- ASA physical status class III-IV
- Providing written informed consent
Exclusion Criteria5
- History of difficult intubation
- Anatomical abnormalities of the upper airway
- Body mass index (BMI) \> 35 kg/m²
- Acute respiratory tract infection
- Emergency surgeries
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Interventions
In this group, the endotracheal tube (ETT) cuff pressure will be maintained at 0 mmHg during cardiopulmonary bypass (CPB)
In this group, the endotracheal tube (ETT) cuff pressure will be maintained at 20-30 mmHg during cardiopulmonary bypass (CPB)
Locations(1)
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NCT07148024