Effect of Probiotic Intervention on Travel-Related Health Conditions During Short-Term Overseas Travel
Universiti Sains Malaysia
46 participants
Jul 31, 2025
INTERVENTIONAL
Conditions
Summary
International travel disrupts gut health through dietary changes, microbial exposure, and stress, often causing gastrointestinal symptoms like traveler's diarrhea and sleep disturbances. These shifts may increase antibiotic resistance risks. Probiotics may help stabilize gut microbiota and improve well-being during travel. This randomized, double-blind, placebo-controlled trial investigated whether probiotic supplementation mitigates gut microbiota perturbations, gastrointestinal symptoms, and sleep issues in adults traveling abroad. The investigators also assessed changes in anxiety, well-being, gut immunity, microbial function, and antibiotic resistance genes.
Eligibility
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Interventions
Daily 6-drops of Bifidobacterium longum subsp. infantis M-63, B. breve M-16V, and B. longum BB536 in non-GMO corn starch as excipient, in medium-chain triglyceride oil (1.5 × 109 CFU/day)
Daily 6-drops of non-GMO corn starch in medium-chain triglyceride oil
Locations(2)
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NCT07163819