RecruitingNot ApplicableNCT07187687

TrIal of Early Minimally Invasive Catheter Evacuation With Thrombolysis in IntraCerebral Hemorrhage

TrIal of Early Minimally Invasive Catheter Evacuation With Thrombolysis in IntraCerebral Hemorrhage (TIME-ICH): A Prospective, Multi-center, Open-label, Adaptive, Randomized Controlled Trial

Sponsor

Xuanwu Hospital, Beijing

Enrollment

750 participants

Start Date

Oct 24, 2025

Study Type

INTERVENTIONAL

Conditions

Intracerebral Hemorrhage

Summary

TIME-ICH (TrIal of early Minimally Invasive catheter Evacuation with thrombolysis in IntraCerebral Hemorrhage) is a multicenter, randomized, adaptive clinical trial comparing best medical management to early minimally invasive surgery with thrombolysis (eMIST) in the treatment of acute spontaneous supratentorial intracerebral hemorrhage.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a procedure called Early Minimally Invasive Surgery with Thrombolysis (eMIST) for people with intracerebral hemorrhage. The study is currently recruiting participants at 50 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREEarly Minimally Invasive Surgery with Thrombolysis (eMIST)

Subjects will undergo minimally invasive catheter evacuation in the early stage of intracranial hemorrhage. Up to 10 doses of 50000U of urokinase will be administered through the catheter that was placed directly into the intracerebral hemorrhage.

Locations(69)

Guangdong Provincial People's Hospital

Guangdong, Yuexiu, China

Baotou Central Hospital

Baotou, China

Beijing Chao-Yang Hospital, Capital Medical University

Beijing, China

Beijing Daxing District People's Hospital

Beijing, China

Beijing Fengtai You'anmen Hospital

Beijing, China

Beijing Friendship Hospital, Capital Medical University

Beijing, China

Peking University Aerospace Central Hospital

Beijing, China

Shunyi District Hospital in Beijing

Beijing, China

Xuanwu Hospital, Capital Medical University

Beijing, China

Bozhou city people's hospital

Bozhou, China

Changsha Central Hospital

Changsha, China

Changzhi Medical College Affiliated Heji Hospital

Changzhi, China

The First People's Hospital of Changzhou

Changzhou, China

Chifeng Municipal Hospital

Chifeng, China

Chongqing Emergency Medical Service

Chongqing, China

Chongqing Red Cross Hospital

Chongqing, China

People's Hospital of Chongqing Banan District

Chongqing, China

First Affiliated Hospital of Dalian Medical University

Dalian, China

Fujian Zhangzhou Municipal Hospital

Fujian, China

Fuxin Second People\'s Hospital

Fuxin, China

Fuyang People's Hospital

Fuyang, China

First Affiliated Hospital of Gannan Medical University

Gannan, China

The Seventh Affiliated Hospital of Southern Medical University

Guangdong, China

Guiyang Second People's Hospital

Guiyang, China

Handan Central Hospital

Handan, China

The First Hospital of Harbin Medical University

Harbin, China

Affiliated Hospital of Hebei University of Engineering

Hebei, China

The First Affiliated Hospital of Anhui Medical University

Hefei, China

Affiliated Hospital of Inner Mongolia Medical University

Hohhot, China

Huizhou First People's Hospital

Huizhou, China

Jinan City People's Hospital

Jinan, China

Jinan Hospital of Xuanwu Hospital, Capital Medical University

Jinan, China

The First People Hospital of Yunnan Province

Kunming, China

Tibet People's Hospital

Lasa, China

Liaocheng Brain Hospital

Liaocheng, China

The First Affiliated Hospital of Nanchang University

Nanchang, China

The First People's Hospital of Nanning

Nanning, China

Affiliated Hospital of Nantong University

Nantong, China

Center Hospital of Nanyang

Nanyang, China

Xingan League People's Hospita

Neimeng, China

The First Affiliated Hospital of Ningbo University

Ningbo, China

University of Chinese Academy of Sciences Ningbo Huamei Hospital

Ningbo, China

Quzhou People's Hospital

Quzhou, China

Third People's Hospital of Hainan Province

Sanya, China

Shanghai Fourth People's Hospital Affiliated to Tongji University

Shanghai, China

Shanghai Sixth People's Hospital Affiliated to Shanghai JiaoTong University

Shanghai, China

Shanghai Tenth People's Hospital

Shanghai, China

First Hospital of Shanxi Medical University

Shanxi, China

The First Affiliated Hospital of China Medical University

Shenyang, China

The First Hospital of China Medical University

Shenyang, China

The First Hospital of Hebei Medical University

Shijiazhuang, China

Taihe Hospital in Shiyan City

Shiyan, China

Suining Central Hospital

Sichuan, China

Central People's Hospital of Siping City

Siping, China

The Second Affiliated Hospital of Shandong First Medical University

Tai’an, China

Tangshan Workers' Hospita

Tangshan, China

Tianjin Huanhu Hospital

Tianjin, China

First Affiliated Hospital of Xinjiang Medical University

Ürümqi, China

Weifang People's Hospital

Weifang, China

The First Affiliated Hospital of Wenzhou Medical University

Wenzhou, China

The Second Affiliated Hospital of Wenzhou Medical University

Wenzhou, China

The First Affiliated Hospital of Xiamen University

Xiamen, China

Xiangyang Central Hospital

Xiangyang, China

Yanan Medical College of Yanan University

Yan’an, China

Yichang Central People's Hospital

Yichang, China

Zhangjiajie City People's Hospital

Zhangjiajie, China

Henan Provincial People's Hospital

Zhengzhou, China

The Second Affiliated Hospital of Zhengzhou University

Zhengzhou, China

The Fourth People's Hospital of Zigong City

Zigong, China

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NCT07187687

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TrIal of Early Minimally Invasive Catheter Evacuation With Thrombolysis in IntraCerebral Hemorrhage

Conditions

Summary

Eligibility

Plain Language Summary

Interventions

Locations(69)

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