TrIal of Early Minimally Invasive Catheter Evacuation With Thrombolysis in IntraCerebral Hemorrhage
TrIal of Early Minimally Invasive Catheter Evacuation With Thrombolysis in IntraCerebral Hemorrhage (TIME-ICH): A Prospective, Multi-center, Open-label, Adaptive, Randomized Controlled Trial
Xuanwu Hospital, Beijing
750 participants
Oct 24, 2025
INTERVENTIONAL
Conditions
Summary
TIME-ICH (TrIal of early Minimally Invasive catheter Evacuation with thrombolysis in IntraCerebral Hemorrhage) is a multicenter, randomized, adaptive clinical trial comparing best medical management to early minimally invasive surgery with thrombolysis (eMIST) in the treatment of acute spontaneous supratentorial intracerebral hemorrhage.
Eligibility
Inclusion Criteria6
- Age ≥ 18 years;
- Pre-randomization head CT demonstrating an acute, spontaneous, primary ICH;
- ICH volume ≥ 20mL as calculated by the ABC/2 method;
- The randomization can be completed within 8 hours after the onset of stroke symptoms (or the time last known to be well), and study intervention can reasonably be initiated within 4 hours after randomization.
- Historical Modified Rankin Score 0 or 1;
- Obtain informed consent from patient or legal representative.
Exclusion Criteria18
- Infratentorial intraparenchymal hemorrhage including midbrain, pontine, or cerebellar;
- Ruptured aneurysm, arteriovenous malformation (AVM), vascular anomaly, Moyamoya disease, venous sinus thrombosis, mass or tumor, hemorrhagic conversion of an ischemic infarct, tumor stroke, recurrence of a recent (\<1 year) ICH, as diagnosed with radiographic imaging;
- Presence of spot sign in CT angiography;
- Blood pressure control before randomization is ineffective, systolic blood pressure \> 220 mmHg;
- Irreversible impaired brain stem function (bilateral fixed, dilated pupils and extensor motor posturing), GCS ≤ 4;
- Hemorrhage with apparent midbrain extension with third nerve palsy or dilated and non-reactive pupils. Other (supranuclear) gaze abnormalities are not exclusions;
- Intraventricular extension of the Hemorrhage is visually estimated to involve \>50% of either of the lateral ventricles;
- Any irreversible coagulopathy or known clotting disorder.
- Platelet count \< 750,000, INR \> 1.4 after correction
- Patients requiring long-term anti-coagulation that needs to be initiated \< 30 days from index ICH;
- Use of 2 or more antithrombotic drugs prior to symptom onset;
- Patients with a mechanical heart valve;
- Positive urine or serum pregnancy test in female subjects without documented history of surgical sterilization or is post-menopausal;
- Urokinase allergy;
- Any concurrent serious illness that would interfere with the outcome assessments including hepatic, renal, gastroenterologic, respiratory, cardiovascular, endocrinologic, immunologic, and hematologic disease;
- Inability or unwillingness of patient or legal representative to give written informed consent;
- Known life-expectancy of less than 6 months;
- Participation in a concurrent interventional medical investigation or clinical trial.
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Interventions
Subjects will undergo minimally invasive catheter evacuation in the early stage of intracranial hemorrhage. Up to 10 doses of 50000U of urokinase will be administered through the catheter that was placed directly into the intracerebral hemorrhage.
Locations(50)
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NCT07187687