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RecruitingNot ApplicableNCT07191262

To Compare Post-Extraction Use of a Novel Ethylenediaminetetraacetic Acid (EDTA) Post-operative Mouth Rinse and Daily Use EDTA Mouth Rinse and Standard 0.12% Chlorhexidine (CHX) Post-operative Mouth Rinse and Daily Use Essential Oil (EO) Mouth Rinse.

A Prospective, Randomized Clinical Trial to Compare Post-extraction Use of a Novel Ethylenediaminetetraacetic Acid (EDTA) Post-operative Mouth Rinse and Daily Use EDTA Mouth Rinse and Standard 0.12% Chlorhexidine (CHX) Post-operative Mouth Rinse and Daily Use Essential Oil (EO) Mouth Rinse.

Sponsor

University of Alabama at Birmingham

Enrollment

40 participants

Start Date

Mar 2, 2026

Study Type

INTERVENTIONAL

Conditions

Extraction Sites After Removal and Bone Replacement Grafting at Extraction Sockets of Dentally Hopeless Single-rooted Teeth

Summary

This study will compare commercially available, commonly used mouth rinses (0.12% chlorhexidine (CHX) vs. Ethylenediaminetetraacetic acid (EDTA)) for immediate post-operative and daily antiseptic use after tooth extraction and ridge preservation grafting followed by daily use of commercially available an essential oil (EO) mouthrinse and EDTA mouthrinse.

Eligibility

Min Age: 18 YearsMax Age: 85 Years

Inclusion Criteria6

  • Able to read and provide informed consent in English
  • At least 18 years old
  • Established and registered patient of the UAB School of Dentistry
  • Patients presenting with one single rooted tooth determined to need extraction and simultaneous ridge preservation bone grafting for future dental implant placement.
  • Presence of periodontally healthy, non-carious neighboring teeth and/or healthy restored dental implants on either side of the tooth planned for extraction.
  • No anticipated need for surgical and/or endodontic care at teeth adjacent to the proposed surgical site during the study period.

Exclusion Criteria7

  • Non-English speaking
  • Age less than 18 years old or older than 85 years old
  • Smokers/nicotine users (\>10 cigarettes or equivalent/day)
  • Patients with systemic pathologies or conditions contraindicating oral surgical procedures or adversely affecting wound healing
  • Multiple adjacent teeth require extraction and grafting
  • Absence of adjacent teeth/implants on either side of the tooth to be extracted.
  • Documented or suspected allergy or sensitivity to any study product
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Interventions

OTHER0.12% CHX and Essential Oil mouthrinse

0.12% CHX mouthrinse will be used to rinse for 1 minute with 15 mL twice daily starting day 1 after surgery through day 14. Patients will be instructed to use OTC essential oil mouthrinse 15mL once daily until the conclusion of the study (day 15 to day 84).

OTHER2.6% EDTA and 0.2% EDTA mouth rinse

.6% EDTA mouthrinse will be used to rinse for 1 minute with 15 mL twice daily starting day 1 after surgery through day 14. Patients will be instructed to use 0.2% EDTA mouthrinse 15mL once daily until the conclusion of the study (day 15 to day 84).

Locations(1)

University of Alabama at Birmingham

Birmingham, Alabama, United States

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NCT07191262