RecruitingNCT07202910

VALidation of Imaging-based Liver Biomarkers in PEDiatric Patients

Imaging-Based Biomarkers for Non-Invasive Pediatric Liver Diagnostics

Sponsor

Sahlgrenska University Hospital

Enrollment

550 participants

Start Date

Mar 28, 2019

Study Type

OBSERVATIONAL

Conditions

MAFLD Hepatic Disorders Intestinal Failure-associated Liver Disease Cystic Fibrosis Liver Disease Pediatric Liver Transplantation

Summary

The goal of this observational (diagnostic validation) study is to validate imaging-based biomarkers for assessing liver involvement in pediatric patients with established or suspected liver disease. The projekt involves 3 larger studies, each with specific aims specified in detailed description below. The main study (study 1) compares imaging-based biomarkers-with liver biopsy to evaluate their correlation with histologically confirmed liver disease, including fibrosis, inflammation, and steatosis. The main question the overall project aims to answer is: • Can multiple novel imaging-based biomarkers, such as shear wave elastography (SWE), shear wave dispersion (SWD), and attenuation imaging (ATI), be used for detailed, non-invasive liver characterization in children, and if so, how should they be used?

Eligibility

Max Age: 25 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a new treatment for people with cystic fibrosis liver disease, hepatic disorders, and other related conditions. The study is currently recruiting participants at 1 location.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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